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hematology infectiousdiseases acidosis chronic classification elevation gastroenterology hemolysis infections leishmaniasis management microbiology mycobacteria nontuberculous ntm oncology pain plasmacytoma solitary thromboticthrombocytopenicpurpura
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... e.g., uptake by cells ... to bolus these values ... 30mmHg) - Severe anemia ... #Diagnosis #causes
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Visceral Leishmaniasis - Diagnosis and Management Summary Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi Where: South Asia, East
Evades innate and cell-mediated ... Lymphadenopathy, Malaise, Abdominal ... Weight Loss • Can cause ... Lymphohistiocytosis • Anemia ... 20 mg/kg/d IV/IM
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
Pain Causes - Differential ... dysfunction • PSC ... malignancy • Lactase ... appendages • FMF ... #Differential #
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... lesions • Lactate ... myeloma Diagnostic ... #Workup #Hematology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Advanced HIV (CD4 cell ... enzymes, diarrhea, abdominal ... Bone Marrow - Anemia ... NTM #Infections #differential
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