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hematology management acidosis agglutinin algorithm arteritis cap causes classification cold community dehydrogenase disease elevated elevation gca giantcell hemolysis hemolytic laboratory
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... enzymes - Acquired ... - Prosthetic valves
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Hyperbilirubinemia • Elevated lactate ... malignancies - B-cell ... younger pts) Differential ... Disorders Such As ... sensitize red blood cells
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... e.g., uptake by cells ... www.ncbi.nlm.nih.gov/pmc ... to bolus these values ... 30mmHg) - Severe anemia
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Pneumonia (CAP) - Diagnosis ... Bands > 15% • Uremia ... negative predictive value ... cultures/nasal PCR ... Pneumonia #CAP #Diagnosis
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... that a one-off value ... Too many cells in ... - Acquired: polycythemia ... #workup #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... (GCA) Giant cell ... or sed rate): Value ... very remarkable w/differential ... systemic complaints- anemia
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... lytic lesions • Lactate ... required Prognosis ... #Workup #Hematology
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