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hematology classification oncology acidosis agglutinin causes chemistry cold dehydrogenase elevated elevation hemolytic hepatology hodgkins interpretation laboratory lactic lfts liver lymphoma
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... ) - Differential ... , sickle cell disease ... - Prosthetic valves ... #LDH #Lactate
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... elevation Serum lactate ... dehydrogenase (LDH ... WBC count and differential ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As ... #hemolytic #anemia
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... e.g., uptake by cells ... to bolus these values ... presentations and disease ... 30mmHg) - Severe anemia
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... muscle, Kidneys • LDH ... intestines, White blood cells ... liver #chemistry #diagnosis ... #differential #
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... classical HL (LDHL ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... number of sites of disease
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• No CRAB - no anemia ... lytic lesions • Lactate ... dehydrogenase (LDH ... diff • CMP, Ca, LDH ... #Workup #Hematology
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