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hematology acidosis agglutinin causes chemistry classification cold dehydrogenase elevated elevation hemolytic hepatology interpretation laboratory lactic lfts oncology plasmacytoma rvalue solitary
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... RBCs, muscle, liver ... , sickle cell disease ... - Prosthetic valves ... #LDH #Lactate
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects, Drugs, Liver ... Defects: Sickle cell ... anemia, Thalassemias
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... elevation Serum lactate ... dehydrogenase (LDH ... WBC count and differential ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As ... #hemolytic #anemia
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... disease: > 2 ... muscle, Kidneys • LDH ... intestines, White blood cells ... #diagnosis #differential
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... e.g., uptake by cells ... to bolus these values ... presentations and disease ... 30mmHg) - Severe anemia
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
common - GI tract, liver ... • No CRAB - no anemia ... lytic lesions • Lactate ... dehydrogenase (LDH ... #Workup #Hematology
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