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algorithm arteritis crisis enlarged erythematosus extravascular gca giantcell hemolytic intravascular macrophage nephrology renal sapho scleroderma signs sle spleen splenomegaly src
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... diagnosis #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm ... • Thrombus (e.g ... Myeloproliferative disorders (eg ... #Diagnosis #Algorithm ... #Causes #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Crisis (SRC) Clinical ... anemia (MAHA) ... other pathology (e.g ... (short-acting, e.g ... Renal #Crisis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Malignancy (e.g ... Endocrine disorders (e.g ... Chronic B-cell activation ... #Rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... them, but urgent rheumatology ... #Management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
out other causes ... antiinflammatory properties e.g ... #Rheumatology # ... diagnosis #management ... #Dermatology
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