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diagnosis differential causes peds rheumatology activation algorithm bleeding bruising dermatology disorders endocarditis erythematosus history infectiousdiseases lupus macrophage management mas naildisorders
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Disorders secondary to Systemic ... Iron deficiency anemia ... halt nail growth (e.g ... • Nephrotic syndrome ... #Secondary #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... with leukopenia, anemia ... Diagnosis #Management #Hematology ... #Rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
- SLE (systemic ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #Causes #peds #pediatrics
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... Endocrine disorders (e.g ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia
Palpitations - Differential Diagnosis Framework What? • It is an unpleasant awareness or sensation that the heart is
exam • 12-lead ECG ... Valvular disease (e.g ... Anticholinergics Systemic ... Hyperthyroidism • Anemia ... #Palpitations #Cardiology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
• Presence of systemic ... Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... #diagnosis #hematology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Vascular: • Systemic ... Cholesterol emboli syndrome ... ↑ ESR, CRP • EKG ... Leukocytosis, anemia ... Differential #Diagnosis #cardiology
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