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diagnosis rheumatology activation bleeding bruising causes differential disorders erythematosus history macrophage management mas primarycare purpura sle thrombocytopenia
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... underlying disease (eg ... lupus erythematosus ... • Infection (eg ... with leukopenia, anemia
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
- SLE (systemic ... lupus erythematosus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
• Presence of systemic ... Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... #pediatrics #diagnosis
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