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diagnosis rheumatology differential management pediatrics primarycare activation arms autoimmune bleeding disorders distribution erythematosus hemeonc hemophagocytic history hlh lupus lymphohistiocytosis macrophage
Characteristic features of the rash are: -Rough texture (like sandpaper) -Worse in the skin folds e.g. groin, axilla,
features of the rash ... the skin folds e.g ... Pastia’s lines) #Clinical ... #Dermatology #Peds
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... Petechial or purpuric rash ... underlying disease (eg ... • Infection (eg ... Diagnosis #Management #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Malignancy (e.g ... Endocrine disorders (e.g ... Clinical Features ... Kidney disease common
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
Common Dermatological ... and pruritus (e.g ... Varies with site, (e.g ... ; pruritis #dermatology ... #rash #differential
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Helpful Clinical ... Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... pediatrics #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
▪ Infections (e.g ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g ... Diagnosis #Management #Hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Inflammatory Myopathies: Commonly ... Aldolase levels • EMG ... Symptoms: • Gottron rash ... flexors, quadriceps, finger ... Myositis #Myopathy #rheumatology
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