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diagnosis differential causes algorithm rheumatology systemic activation antibodies associations autoantibodies chronic dermatology diseases elevatedmcv endocarditis erythematosus extravascular fatigue hemolysis hemolytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
La) - Sjogren's syndrome ... - Vasculitis, e.g ... - Vasculitis, e.g ... #diagnosis #table ... #rheumatology #
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Iron deficiency anemia ... halt nail growth (e.g ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Increased Requirement (e.g ... • Pancreatic Disease ... Myelodysplastic Syndromes ... • Liver Disease ... Algorithm #Causes #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Obstructive Pulmonary Disease ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(eg, systemic juvenile ... • Infection (eg ... with leukopenia, anemia ... Diagnosis #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia
Palpitations - Differential Diagnosis Framework What? • It is an unpleasant awareness or sensation that the heart is
exam • 12-lead ECG ... (sick sinus syndrome ... (e.g., aortic insufficiency ... Hyperthyroidism • Anemia ... #Palpitations #Cardiology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Congenital heart disease ... Cholesterol emboli syndrome ... ↑ ESR, CRP • EKG ... Leukocytosis, anemia ... Differential #Diagnosis #cardiology
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