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diagnosis differential rheumatology algorithm anemia associations autoantibodies autoimmune causes coagulation crystals deficiencies deficiency diseases elevatedmcv erythematosus hyperthermic lupus macrocytic macrocytosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- Vasculitis, e.g ... - Vasculitis, e.g ... #diagnosis #table ... #rheumatology # ... antibodies
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Autoimmune disorders (e.g ... #comparison #diagnosis ... #hematology #deficiency
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Increased Requirement (e.g ... B12 - Anti-IF Antibodies ... B12 - Anti-IF Antibodies ... Myelodysplastic Syndromes ... Algorithm #Causes #Hematology
Urine Microscopy Crystals Uric Acid crystals: - Formation promoted by acidic urine - Seen in tumor lysis
in tumor lysis syndrome ... specific systemic disease ... urease-producing organisms (e.g ... Microscopy #Crystals #comparison ... #table #urinalysis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
Hyperthermic Toxidromes Five toxidromes may present with overlapping features: hyperthermia, rhabdomyolysis, altered mental status/seizures. • Sympathomimetic -
• Serotonin Syndrome ... dopamine blockers (e.g ... dopamine agonists (e.g ... pharmacogenetic disease ... #table #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Aldolase levels • EMG ... Antisynthetase syndrome ... ANTI-SYNTHETASE SYNDROME ... paraneoplastic syndrome ... Myositis #Myopathy #rheumatology
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