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diagnosis differential causes algorithm anemia rheumatology systemic antibodies associations autoantibodies bleeding clinical coagulation crystals deficiencies dermatology diseases disorders echocardiogram elevatedmcv
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Autoimmune disorders (e.g ... #comparison #diagnosis ... #hematology #deficiency
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... G6PD deficiency) ... differential #diagnosis #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
La) - Sjogren's syndrome ... - Vasculitis, e.g ... - Vasculitis, e.g ... #diagnosis #table ... #rheumatology #
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Dietary Deficiency ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... • Liver Disease ... Algorithm #Causes #Hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Spoon-shaped • Iron deficiency ... halt nail growth (e.g ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
Urine Microscopy Crystals Uric Acid crystals: - Formation promoted by acidic urine - Seen in tumor lysis
in tumor lysis syndrome ... specific systemic disease ... urease-producing organisms (e.g ... Microscopy #Crystals #comparison ... #table #urinalysis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... • Prolidase deficiency ... vein thrombosis Hematologic
This infographic provides a mnemonic tool called “WOBBLER” for assessing an ECG (electrocardiogram) in cases of
for assessing an ECG ... section of the ECG ... structural heart disease ... • Efficiency: ... #cardiology #differential
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Drug history, e.g ... connective tissue, e.g ... Marfan syndrome, ... or factor XIII deficiency ... pediatrics #diagnosis #hematology
Hyperthermic Toxidromes Five toxidromes may present with overlapping features: hyperthermia, rhabdomyolysis, altered mental status/seizures. • Sympathomimetic -
• Serotonin Syndrome ... dopamine blockers (e.g ... dopamine agonists (e.g ... pharmacogenetic disease ... #table #diagnosis
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