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diagnosis neurology hematology pulmonary toxicity amiodarone b12 barre bells cobalamin deficiency differential encephalopathy gravis guillain hemeonc hemophagocytic hlh induced leukostasis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Dehydration • Symptoms ... changes, stroke symptoms ... unless worrisome EKG ... TLS #diagnosis #management
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
any time during treatment ... (GBS), systemic ... (SAMS-CI) • EMG ... myopathy #diagnosis #management ... #treatment
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... than one after symptom ... Electrodiagnostic studies (Ex EMG ... and cauda equina TREATMENT ... #diagnosis #management
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
muscles: “myasthenic crises ... PCB variants of GBS ... Serologic and EMG ... Myasthenia Crises ... Gravis #diagnosis #management
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy Presentation:
Imaging (if atypical symptoms ... LP (if suspect GBS ... CNS inflammatory cause ... ) • EMG/NCS (rare ... #Treatment #Neurology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
recent DAN) • EMG ... or serologies + symptoms ... Goodpasture's cause ... differential #diagnosis #management ... #treatment
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dietary intake (e.g ... organ ischemia (e.g ... Check for IF ab Treatment ... other diagnosis e.g
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Neurological symptoms ... • EEG: With persistent ... the underlying cause ... • Treatment of ... #diagnosis #management
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
Acute toxicity (e.g ... respiratory distress syndrome ... Chronic toxicity (e.g ... gradually with symptoms ... Pulmonary #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... ▪ Infections (e.g ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g
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