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diagnosis classification differential symptoms erythematosus hemophagocytic hlh lymphohistiocytosis oncology sle syndrome systemic antinxp2 antinxp2dm arteritis behcet cryoglobulinemia cryoglobulins dermatology dermatomyositis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... Butterfly rash, Vasculitis ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... Syndrome: - Ocular ... such as systemic lupus ... purpura: strong sign ... differential #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Erythematous, macular ... Non-autoimmune rheumatologic ... sediment, and elevated ... Erythematosus #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... cryoglobulins • Elevated ... (e.g. systemic lupus ... classification #rheumatology ... #vasculitis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... Behcet syndrome (Clinical ... Syndrome #diagnosis #management ... #signs #symptoms ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... Mono Multiplex, Elevated ... ulcers, cutaneous, ocular ... Cogan syndrome: Ocular ... Differential #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... Diagnosis: HLH signs ... >500 ng/mL • Elevated ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
syndrome • Erythema elevatum ... Autoimmunity: • -MM/WM: Vasculitis ... Vasculitis) Autoantibodies ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... Diagnosis = clinical ... systemic sx + signs ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
• Serum IgG4 elevated ... specific) COMMON CLINICAL ... aortitis, mimics vasculitis ... Essential Criteria: Clinical ... #Rheumatology
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