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diagnosis differential liver algorithm apml chemistry cll differentiation hepatitis injury interpretation leukemia lfts lymphocytic monoclonal paraproteinemias rvalue transaminitis workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Elevated LDH 5. ... Elevated beta 2 ... diagnosis #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... if WBC > 5 or elevated ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
specificity to elevated ... > 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... • Gilbert's syndrome ... #differential #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
vein: Budd-chiari syndrome ... specificity to elevated ... > 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... • Erythema elevatum ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
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