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differential treatment signs algorithm neurology pathophysiology rheumatology gastroenterology cardiology hematology causes disease hepatology syndromes table criticalcare infectiousdiseases endocrinology comparison clinical
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... tumor burden • Symptoms ... #TLS #diagnosis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... HLH signs and symptoms ... >500 ng/mL • Elevated ... soluble CD25 • Elevated ... #management #treatment
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
Inflammatory Cytokine Syndrome ... Symptoms: Fatigue ... inflammation - Elevated ... #Kaposi #diagnosis ... #management #hhv8
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
factor PRES Diagnosis ... Neurological symptoms ... CSF: Modestly elevated ... An elevated white ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... if WBC > 5 or elevated ... : >3 symptoms, or ... Differentiation #Syndrome ... #management #hematology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Puncture: - Elevated ... than one after symptom ... Guillain #Barre #Syndrome ... #diagnosis #management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
and the systemic symptoms ... Histopathological Diagnoses ... Thrombocytopenia - Elevated ... agonists #TAFRO #diagnosis ... #management #rheumatology
Gestational Hypertension & Preeclampsia Gestational Hypertension (gHTN) • BP > 140/90 • Onset > 20 wks gestation
Thrombocytopenia • Elevated ... Cerebral/visual symptoms ... Seizure HELLP Syndrome ... Thrombocytopenia • Elevated ... Classification #Diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Pancreatitis - Elevated ... - Budd Chiari Syndrome ... pathophysiology #signs #symptoms ... #diagnosis
Ramsay Hunt Syndrome - Herpes Zoster Oticus Triad: 1. Ipsilateral facial paralysis 2. Ear pain 3. Vesicles
Ramsay Hunt Syndrome ... Guillain-Barré syndrome ... • Stroke syndromes ... HerpesZoster #Oticus #Diagnosis ... #Symptoms #Signs
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