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differential oncology management hemolytic leukemia acute aplastic chronic classification cll disorders eosinophilia hemolysis hodgkins injury kidney leukostasis lymphocytic lymphoma lysis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... (common causes ... organ-specific signs ... #Differential #diagnosis ... #hematology #eosinophilia
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... Hemolysis #Hemolytic #Anemia ... #Causes #Workup ... #Hematology #Diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Workup Algorithm ... and Differential Diagnosis ... clinical context and signs ... Interstitial nephritis: eosinophilia ... #Workup #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... bartonella (oroya fever ... #Algorithm #workup ... #hematology #testing
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... and petechiae Causes ... - Hepatitis, eosinophilic ... #oncology #hematology ... #diagnosis #management
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Red Flags: • Fever ... deficiency Work ... #Algorithm #Causes ... #dermatology #physicalexam
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - 80% have fever ... - ACS, AKI, ... WBC >100k, + lab signs ... #management #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... Physical Exam/Signs ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... classification #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... • (Peripheral eosinophilia ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
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