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management oncology differential aplastic hemolytic leukemia causes chronic classification cll disorders eosinophilia hemeonc hemolysis hemophagocytic hlh hodgkins leukostasis lymphocytic lymphohistiocytosis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... , 500-1,500 cells ... organ-specific signs ... #Differential #diagnosis ... #hematology #eosinophilia
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... Increased red cell ... #Causes #Workup ... #Hematology #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... cells - Consider ... bartonella (oroya fever ... #Algorithm #workup ... #hematology #testing
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Diagnosis: • Pancytopenia ... Consider stem cell ... if neutropenic fever ... #treatment #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... Physical Exam/Signs ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... corpuscular (cell ... Red cell distribution ... #Algorithm #Diagnosis ... #Workup #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... - Hepatitis, eosinophilic ... #oncology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... • (Peripheral eosinophilia ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... - ACS, AKI, ... WBC >100k, + lab signs ... Lysis of tumor cells ... #management #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... classification #hematology
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