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ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated ... pathologically or clinically ... polyangiitis (GPA ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
• EGPA: - Eosinophilia ... +MPO) • Cryoglobulinemic ... bullous or vesicular eruption ... and branches • GCA ... Low levels mixed cryoglobulinemia
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Elevated ESR and CRP GCA ... develop in pts with GCA ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... + MPO) Cryoglobulinemic
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... arthralgia, and arthritis ... DDX: • ANCA (Antineutrophil ... associated vasculitis - GPA ... SLE), rheumatoid arthritis