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diagnosis rheumatology vasculitis differential classification sle algorithm cryoglobulinemia cryoglobulins druginduced erythematosus management systemic table types vasculitides
ANCA-Associated Vasculitis There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated ... pathologically or clinically ... polyangiitis (GPA ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... inflammation Others: • Lupus ... bullous or vesicular eruption ... and branches • GCA ... such as systemic lupus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms, Arthritis ... 40, F:M 9:1 • Clinical ... #sle #comparison ... #table #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Elevated ESR and CRP GCA ... develop in pts with GCA ... bullous or vesicular eruption ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... macular, patchy eruption ... Diagnosis: • ANCA-associated ... lymphoproliferative syndrome Clinical ... vein thrombosis Hematologic
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... arthralgia, and arthritis ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... SLE), rheumatoid arthritis
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