8 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil ... #diagnosis #types
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Lupus Nephritis, Cryoglobulinemia ... • Limited to Kidney ... #differential #diagnosis ... #algorithm #rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... and Differential Diagnosis ... osmolarity If cause ... Glomerulonephritis / Vasculits: ANCA ... immunoglobulins, cryoglobulins
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - APLS • Acute ... vasculitis/HSP • Cryoglobulinemia ... (MIXED) • ANCA ... Associated - SLE, Sjogren's
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... +MPO) • Cryoglobulinemic ... Kidneys -> glomerulonephritis ... Serologies for Cryoglobulins ... #rheumatology #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... Differential Diagnosis ... dermatomyositis, Sjogren ... C4) • ds-DNA: Kidney ... induced SLE • Kidney
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... musculoskeletal systems • Kidneys ... tract, and often causes ... + MPO) Cryoglobulinemic ... #Rheumatology
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
seronegative) • Kidneys ... Most common • Sjogren ... /EGPA • RA Diagnosis ... Nonspecific ↑ ESR, CRP, ANA ... #diagnosis #management