6 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Skin ulcers - Glomerulonephritis ... Cause Organ Damage ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Lupus Nephritis, Cryoglobulinemia ... • Limited to Kidney ... #differential #diagnosis ... #algorithm #rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... and Differential Diagnosis ... osmolarity If cause ... and signs • Glomerulonephritis ... immunoglobulins, cryoglobulins
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... +MPO) • Cryoglobulinemic ... Kidneys -> glomerulonephritis ... Serologies for Cryoglobulins ... #rheumatology #
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - APLS • Acute ... vasculitis/HSP • Cryoglobulinemia ... (MIXED) • ANCA ... Associated - SLE, Sjogren's
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... musculoskeletal systems • Kidneys ... tract, and often causes ... + MPO) Cryoglobulinemic ... #Rheumatology