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rheumatology differential vasculitis algorithm classification management aki champs complement dermatology erythematosus hypocomplementemia injury low lupus mnemonic nephrology nonpalpable palpable polychondritis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Skin ulcers - Glomerulonephritis ... Cause Organ Damage ... DDX: • ANCA (Antineutrophil ... #diagnosis #types
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Lupus Nephritis, Cryoglobulinemia ... • Limited to Kidney ... #differential #diagnosis ... #algorithm #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... autoimmune (RA, Sjogren's ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... and Differential Diagnosis ... osmolarity If cause ... and signs • Glomerulonephritis ... immunoglobulins, cryoglobulins
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... +MPO) • Cryoglobulinemic ... Kidneys -> glomerulonephritis ... Serologies for Cryoglobulins ... #rheumatology #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - APLS • Acute ... vasculitis/HSP • Cryoglobulinemia ... (MIXED) • ANCA ... Associated - SLE, Sjogren's
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... TYPE IV RTA, TYPE ... acidosis • NAGMA • Glomerulonephritis ... Nephrogenic DI Hematologic ... Vasculitis: • 7%, Cryoglobulinemia
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... musculoskeletal systems • Kidneys ... tract, and often causes ... + MPO) Cryoglobulinemic ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... Differential Diagnosis ... : • ANCA-associated ... dermatomyositis, Sjogren ... Kikuchi disease • Type-I
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
seronegative) • Kidneys ... Most common • Sjogren ... /EGPA • RA Diagnosis ... Antibodies to type ... #diagnosis #management
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