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differential rheumatology algorithm aki classification nephrology dermatology erythematosus glomerulonephritis lupus nonpalpable palpable progressive purpura rapidly rpgn sle systemic types vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
causing endothelial injury ... • They can cause ... Cause Organ Damage ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM ... immunoglobulins, cryoglobulins ... #Kidney #Injury
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... +MPO) • Cryoglobulinemic ... Kidneys -> glomerulonephritis ... Serologies for Cryoglobulins ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Lupus Nephritis, Cryoglobulinemia ... • Limited to Kidney ... Glomerulonephritis #Vasculitis ... #differential #diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... #Kidney #Injury ... #nephrology #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- APLS • Acute ... /HSP • Cryoglobulinemia ... (MIXED) • ANCA ... Associated - SLE, Sjogren's ... #hematology #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... musculoskeletal systems • Kidneys ... tract, and often causes ... + MPO) Cryoglobulinemic ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... Differential Diagnosis ... : • ANCA-associated ... dermatomyositis, Sjogren ... C4) • ds-DNA: Kidney
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