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diagnosis rheumatology differential dermatology treatment vasculitis cerebritis classification cns cryofibrinogenemia cryoglobulins erythematosus gravis hepatology hepatopulmonary inflammatory lupus myasthenia myelitis nonpalpable
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
CAUSES OF NON-PALPABLE ... CAUSES OF PALPABLE ... vasculitis/HSP • Cryoglobulinemia ... Associated - SLE, Sjogren's ... Differential #Diagnosis #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... triad of Palpable ... • Autoimmune diseases ... syndrome) #Cryoglobulinemia
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... Inflammatory causes ... • Sjögren syndrome ... optica spectrum disorder ... #Syndromes #neurology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Nephrogenic DI Hematologic ... Vasculitis: • 7%, Cryoglobulinemia ... #Syndrome #Rheumatology ... #Diagnosis #Management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... Erythematosus #SLE #CNS #neurology ... cerebritis #diagnosis #management
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Can Be ... Associated Disorders ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
affects the skin, neurologic ... cognitive impairment, neurologic ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... vasculitis • Cogan syndrome
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
for NMO, SLE or Sjogren's ... • Infectious causes ... - Sjogren - ... Myelitis #diagnosis #management ... #neurology #differential
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
an autoimmune disorder ... Autoimmune: thyroid, Sjogren ... failure - Can be ... Gravis #diagnosis #management ... #neurology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
chronic inflammatory disorder ... Autoinflammatory disorder ... Rule out other causes ... osteoarticular and skin disease ... diagnosis #management
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