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diagnosis anca antibody antineutrophil antinuclear classification dermatology diseases erythematosus gravis hematology lupus myasthenia myelitis nonpalpable palpable polychondritis purpura relapsing systemic
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... • Sjögren syndrome ... Vasculitis: • ... #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Kasabach-Merritt syndrome ... Associated - SLE ... , Sjogren's ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... Hypocomplementemia • Can cause ... #Syndrome #Rheumatology ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... dermatomyositis, Sjogren ... syndrome, and mixed ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
renal abnormalities ... often causes arthritis ... ) pattern: antibodies ... , and SLE) • Urinalysis ... #rheumatology #
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
autoimmune disorder ... Autoimmune: thyroid, Sjogren ... arthritis, SLE ... life-threatening Differential ... #neurology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... renal abnormalities ... Vasculitis Differential ... , such as SLE, atherosclerotic ... #Rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Infectious causes ... Vasculitis- Heroin ... Antiamphiphysin antibodies ... Myelitis #diagnosis #management ... #neurology #differential
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
body (Autoimmune disorder ... as: • SLE • RA ... Most common • Sjogren ... Heart failure • Renal ... #diagnosis #management
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