11 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Syndrome: • Clinical ... lupus erythematosus ... syndrome) #Cryoglobulinemia ... diagnosis #types #classification
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Behcet disease, Cryoglobulinemia ... lupus erythematosus ... , Rheumatoid arthritis ... #differential # ... diagnosis #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... mucositis - Rash ... lupus erythematosus ... , and SLE) • Urinalysis ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... Skin Disease Classification ... rashErythematous ... permanent alopecia Differential
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... Syndrome (SS), ... (SLE), Systemic ... rheumatology #diagnosis #differential
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Diagnosis Algorithm ... - (Reiter’s syndrome ... Lupus Erythematosus ... (SLE), should have ... like “butterfly rash
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... , Vasculitis, Purpura ... of hip (rare), Arthritis ... Demyelinating syndromes ... #systemic #erythematosus
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... diseases, such as SLE ... ischemia • Skin: Erythematous ... , mucositis • Rash ... / ANCA + MPO) Cryoglobulinemic
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... • Giant cell arteritis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Systemic disease ... skin injury) • Neurologic ... (Clinical Dx). ... Behcet disease) Differential ... : SLE, Reactive