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diagnosis hematology oncology management types anemia aplastic bruising cryofibrinogenemia cryoglobulinemia cryoglobulins differential disease hemostasis hodgkins leukemia lymphoma vasculitis vonwillebrand
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can activate ... • They can cause ... : • Clinical triad ... diagnosis #types #classification ... #rheumatology #
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Tyrosine Kinase activity ... -> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Willebrand factor activity ... ristocetin cofactor activity ... von Willebrand syndrome ... discern these causes ... Differential #Diagnosis #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... ecchymoses, mucosal bleeding ... and petechiae Causes ... Anemia #oncology #hematology
Von Willebrand Disease Classification Type 1 (Accounts for ~3/4 of cases): • Defect: Quantitative defect (i.e. not
Willebrand Disease Classification ... (uncommon) • Bleeding ... : Severe (Clinically ... VonWillebrand #Disease #Classification ... Types #diagnosis #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... Diagnosis: • + Clinical ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... ) Classification ... • PET scan - activity ... lymphoma #diagnosis #classification ... #hematology #oncology
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