16 results
Sweet’s Syndrome - Acute febrile neutrophilic dermatosis 

The syndrome involves fever, painful rash, neutrophilic leukocytosis, and
febrile neutrophilic dermatosis ... fever, painful rash ... #neutrophilic #dermatosis ... #dermatology #Rash ... #Skin #Clinical
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Pigmented Purpuric Dermatosis ... vasculitis - GPA ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Maculopapular rash ... • Goodpasture syndrome ... #dermatology #rash
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Neutrophilic dermatoses ... - Rash: multiple ... Causes: - Idiopathic ... , breast CA - Hematologic ... #diagnosis #dermatology
Pustular Skin Lesions - Differential Diagnosis Framework

What are pustules?
• Pustules < 5-10 mm + pus
• Material
Generalized itchy rash ... Erosive pustular dermatosis ... SAPHO syndrome ( ... Sweet syndrome ... Differential #Diagnosis #Dermatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can activate ... • They can cause ... Cryoglobulins Cause ... : • Clinical triad ... associated vasculitis - GPA
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Clinical Presentation ... Fever is the main clinical ... manifestations: from easy bruising ... Petechial or purpuric rash ... Diagnosis #Management #Hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... and neutrophilic dermatoses ... Diagnosis: • A clinical ... Rule out other causes ... diagnosis #management #Dermatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Bleeding and Bruising ... Willebrand factor activity ... von Willebrand syndrome ... discern these causes ... Differential #Diagnosis #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Tyrosine Kinase activity ... -> AML: Blast crises ... PLT: Petechiae, bruising ... • Tumor lysis syndrome ... #Leukemia #Hematology