363 results
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
Pathophysiology EXOGENOUS ... components Exogenous ... , IFN, IL-6 ENDOGENOUS ... vasculature via: • Active ... organs CNS - Endogenous
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm
Exogenous (ACTH-independent)
Endogenous
 • ACTH-dependent:
    - ACTH-secreting
) - Simplified Differential ... Diagnosis Algorithm Exogenous ... ACTH-independent) Endogenous ... Cushings #syndrome #Differential
Staging of Skin Mottling

Mottling is less sensitive, but more specific for hypoperfusion and elevated mortality (figure
Mottling suggests active ... endogenous vasoconstriction ... not additional exogenous
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Hyperphosphatemia - Differential ... Phosphate Load: • Exogenous ... Fosphenytoin • Endogenous ... Hyperphosphatemia #Differential
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: → Exogenous ... pro-inflammatroy mediators (Endogenous ... Pyrogen) → Endogenous ... vasculature via: • Active ... circumventricular organs CNS: Endogenous
Thyroid Disorders - Differential Diagnosis Algorithm
Hypothyroidism:
 • Hasimoto’s
 • Radioactive Iodine 
 • Hypopituitarism
 • Iodine
Thyroid Disorders - Differential ... Thyroiditis • Exogenous ... Thyroid #Disorders #Differential
Polyuria - Differential Diagnosis
Solute Diuresis
 • Na intake/saline
 • Glucosuria: Hyperglycemia, SGLT-2 inhibitors
 • Urea: Exogenous
Polyuria - Differential ... inhibitors • Urea: Exogenous ... #Polyuria #Differential
Headache Differential - Primary vs Secondary
A vast number of diseases can cause a headache. We divide
Headache Differential ... caused by various exogenous ... #Diagnosis #Differential
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Noncardiogenic Pulmonary ... Edema - Differential ... renin-angiotensin-aldosterone system activity ... hemorrhage, seizure activity ... #edema #NCPE #differential
Pulmonary Embolism on POCUS Echocardiogram

Mid 30's female with chest pain/dyspnea.  Triage EKG (no prior).
Pulmonary Embolism ... Differential/diagnosis ... Activate cath lab ... thread for POCUS Pulmonary ... RJonesSonoEM #Pulmonary