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Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm Urine chloride < 20 mmol/l - Chloride responsive (Chloride
Causes of Metabolic Alkalosis ... Severe K depletion, Exogenous ... #Metabolic #Alkalosis
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Pathophysiology EXOGENOUS ... components Exogenous ... proinflammatory mediators (endogenous ... , IFN, IL-6 ENDOGENOUS ... organs CNS - Endogenous
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm Exogenous (ACTH-independent) Endogenous • ACTH-dependent: - ACTH-secreting
Diagnosis Algorithm Exogenous ... ACTH-independent) Endogenous
Hypoglycemia - Evaluation Algorithm Interpreting Hypoglycemia Labs - the patient must be hypoglycemic at the time of
Proinsulin - Is it endogenous ... → Exogenous Insulin
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Phosphate Load: • Exogenous ... Fosphenytoin • Endogenous
Staging of Skin Mottling Mottling is less sensitive, but more specific for hypoperfusion and elevated mortality (figure
suggests active endogenous ... not additional exogenous
Blood Gas Analysis and Interpretation STEPS TO ANALYSIS 1. Look at PH. Alkalotic or acidotic?
Alkalotic or acidotic ... - If alkalotic, ... then it is an alkalosis ... respiratory component) - alkalotic ... metabolic component) - alkalotic
Arterial Blood Gas (ABG) Analysis - Metabolic + Respiratory Acidosis + Alkalosis pH ↓ pCO2 ↓ -
Respiratory Acidosis + Alkalosis ... ↑ - Metabolic alkalosis ... - Respiratory alkalosis ... Compensation #acidosis #alkalosis
Arterial Blood Gas (ABG) Interpretation • AG/non-AG Metabolic Acidosis • AG Acidosis "Delta/Delta" • Metabolic Alkalosis
• Metabolic Alkalosis ... • Respiratory Alkalosis ... acidbase #acidosis #alkalosis
Acid-Base Disorders - Differential Diagnosis Framework • Respiratory Acidosis • Respiratory Alkalosis • Metabolic Acidosis •
• Respiratory Alkalosis ... • Metabolic Alkalosis ... diagnosis #acidosis #alkalosis
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