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diagnosis management rheumatology treatment erythematosus hepatology hepatopulmonary lupus systemic cerebritis chronic classification cll cryoglobulinemia cryoglobulins differential hemophagocytic hlh hps immune
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
) Clinical Manifestations ... Demyelinating Syndrome ... Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... /aggregate) of CD4 ... salivary ducts Clinical ... primary biliary cirrhosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Clinical Features ... and CNS • Headache ... titers > 1:80 • CBC
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... : SLE+++, Adult-onset ... management #treatment #summary ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • They can cause ... : • Clinical triad ... • Autoimmune diseases ... : - 10% SLE or
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... cells can indicate disease ... workup #oncology #hematology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... and Management Summary ... Caused by intrapulmonary ... shunt (Type 2) Clinical ... with or without cirrhosis
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... worsening of that disease ... initiation Clinical ... pleural effusions, CNS ... progression of cirrhosis
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
erythematosus (SLE ... IGG4 - Hepatic cirrhosis ... cell lymphoma Pathophysiology ... histopathologic changes in LNs ... diagnosis #management #rheumatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
abnormalities PATHOPHYSIOLOGY ... arteriovenous shunting causes ... of orthodeoxia CLINICAL ... • Stigmata of cirrhosis ... #hepatology
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