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hematology differential management hodgkins lymphoma syndrome vasculitis workup allergic allergy causes champs chronic clinical cll comparison complement cryofibrinogenemia cryoglobulinemia cryoglobulins
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
surfaces • Ex: Autoimmune ... Gravis, Graves' Disease ... complexes • Ex: Systemic ... #Classification ... #Diagnosis #Definitions
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... skin thickening Signs ... interstitial lung disease ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
EBV infection, Autoimmune ... : Classification ... on: - Cell type ... NonHodgkins #comparison #oncology ... #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... diseases: - 10% ... Labs/Diagnosis: ... #types #classification ... #rheumatology #
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Chain deposition disease ... Atypical HUS, autoimmune ... glomerulonephritis (>90%) S - Systemic ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... immunotactoid GN, Type ... Ig deposition disease ... #Differential #Diagnosis ... #hematology #oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... IV RTA, TYPE I ... RTA Diagnosis: ... Central nervous system ... Sjogrens #Syndrome #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... • Non-autoimmune ... rheumatologic diseases ... • Type-I Interferonopathies ... #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Divided Into Two Types ... associated with autoimmune ... processes: • Systemic ... Cryofibrinogenemia Diagnosis ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... Differential Diagnosis ... purpura: strong sign ... #rheumatology # ... classification
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