18 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... : • Clinical triad ... HBV infection, HIV ... Labs/Diagnosis:
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... osmolarity If cause ... investigations depending on clinical ... Glomerulonephritis / Vasculits ... immunoglobulins, cryoglobulins
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Causes of Knee Effusions ... - Differential Diagnosis ... #Effusions #causes ... #differential #diagnosis ... #msk #physicalexam
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... tract, and often causes ... • Cogan Syndrome ... Serologies for Cryoglobulins ... • HIV • HBV
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... - Differential Diagnosis ... ITP - APLS - HIT ... immunoglobulins & cryoglobulins ... #dermatology #physicalexam
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... : • + Clinical ... • Negative causes ... • TTP, HUS and HIT ... Antiphospholipid syndrome
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Pathogenesis and Clinical ... nephrotic/nephritic syndrome ... arthritis (especially knees ... and ankles) #HSP ... Pathophysiology #Diagnosis
Palpable Purpura seen in Henoch Schonlein Purpura (HSP, IgA Vasculitis)

55 year old male on tuberculosis treatment
, IgA Vasculitis ... pain involving knees ... #IgA #Vasculitis ... #clinical #photo ... dermatology #skin #rash #physicalexam
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... Diagnosis: • hemolytic ... Mycoplasma, EBV, HIV
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... DTR’s • Onset: Few ... Guillain-Barre Clinical ... Guillain-Barre Diagnosis ... #diagnosis #management