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hematology causes differential pt abnormal prolonged anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran dic disseminated edoxaban hemostasis heparin inhibitor
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... Congenital intrinsic coagulation ... intravascular coagulation ... Prolonged #Causes #diagnosis ... differential #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Prolonged PT and aPTT ... the PT and the aPTT ... Prolonged #Causes #diagnosis ... differential #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT/PTT ... levels of factors VII ... Thromboembolism (7%) • CNS ... INR < 2.3 - APTT ... #diagnosis #causes
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... complexes with FVIIa ... TF-FVIIa also activates ... thrombin #clot #PT #PTT ... #diagnosis #models
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... evaluation of factor VII ... intravascular coagulation ... #Differential #Diagnosis
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