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Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... typically prolong PT ... Prolonged PT and ... #Abnormal #PT
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... , FVII, FIX, FX ... , FVII, FIX, FX) ... #Abnormal #PT
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Prothrombin Time (PT ... Prothrombin Time (PT ... warfarin) • Factor VII ... thematttsai #PT
Light's Criteria for Pleural Effusions

#Diagnosis #Pulmonary #Lights #Criteria #Pleural #Effusion #Differential

** GrepMed Recommended Text: Pocket Medicine:
Criteria for Pleural Effusions ... Criteria #Pleural #Effusion
One-page resource for Lung POCUS in COVID19:
- likely (unproven) sensitive due to peripheral distribution of lesions
CT - pleural effusions ... uncommon - if pt
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged PT ... • Prolonged PT ... • Prolonged PT ... Prolonged PTT, Normal PT ... Prolonged #PPT #PT
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Causes of Knee Effusions ... Framework Knee Effusion ... Infectious Knee Effusions ... Traumatic Knee Effusions ... Malignant Knee Effusions
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
complexes with FVIIa ... TF-FVIIa also activates ... thrombin #clot #PT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
== NORMAL PT ... level NORMAL PT ... If the PT remains ... evaluation of factor VII ... Inherited: • Factor VII
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm

aPTT: Intrinsic / Final
PT: Extrinsic / Final

By
Elevated aPTT / PT ... Intrinsic / Final PT ... Elevated #aPTT #PT