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differential algorithm management clinical causes cardiology radiology pocus pulmonary table signs comparison neurology symptoms pathophysiology treatment classification nephrology hematology peds
Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
Diagnostic Schema ... Hyperferritinemia Pearl: Diseases ... Still's disease ... histoplasmosis #Ferritin ... #Differential #Diagnosis
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... , difficult to diagnose ... CRP, AST+ALT, ferritin ... AOSD: F>M, low ferritin ... AdultOnset #Stills #Disease
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
- Differential Diagnosis ... Algorithm Labs: Ferritin ... Structural: Celiac disease ... #Differential #Diagnosis ... #Algorithm #ferritin
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
anemia of chronic disease ... following approach: #Diagnosis ... Anemia #Algorithm #Ferritin
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Onset Still's Disease ... • Leukocytosis Diagnosis ... widely used for diagnosis ... onset #Stills #disease ... #AOSD #diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... MCHC, Serum Iron, Ferritin ... Anemia of Chronic Disease ... #Differential #Diagnosis
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
patients with anemia, diagnose ... deficiency if: • Ferritin ... Test for celiac disease ... Evaluation #workup #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... dysfunction, ↑ Ferritin ... • Autoimmune diseases ... Adult-onset Still disease ... Lymphohistiocytosis #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... Presentation / Diagnosis ... Diagnosis via genetic ... cell activity • Ferritin ... Infection should be diagnosed
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
highly inflammatory disease ... Adult-onset Still disease ... of underlying disease ... dehydrogenase • ↑ Ferritin ... Activation #Syndrome #Diagnosis
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