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diagnosis hematology management mds myelodysplastic chronic cll differential gap lymphocytic myelodysplasia protein proteingap syndromes treatment workup
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Headaches • Pale skin ... #Aplastic #Anemia ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute leukemia ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Neutropenia, anemia ... Pure red cell aplasia ... increase in gamma globulins ... diagnosis #workup #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Hematology #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... • Aplastic Anemia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Plasma cell leukemia ... gammopathy, and skin ... changes (POEMS syndrome ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia
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