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hematology differential management oncology dermatomyositis leukemia product reactions vasculitis agglutinin anemia antimda5 antimda5dm antinxp2 antinxp2dm chronic classification clinical cll cold
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... organ-specific signs ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous ... chest (in a V-sign ... onset [33-74%] • Blood ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Most common extra cutaneous ... Episcleritis Signs ... neutrophils in the blood ... Sweet #Syndrome #diagnosis ... #dermatology #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
aphthous ulcers, cutaneous ... purpura: strong sign ... pulses, bruis, or blood ... Large Vessel: Blood ... #rheumatology #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
nose, ears, or fingers ... presentation) • Cutaneous ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... hemolytic #anemia #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... purpura: Strong sign ... pulses, bruits, or blood ... episcleritis as well as inner ... #Rheumatology
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
associated with signs ... soles, sides of fingers ... - Trunk - Red, blood-filled ... ; pruritis #dermatology ... #differential #diagnosis
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... • Major blood ... osteomyelitis or skin ... scalp, vagina, fingers ... have positive blood
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... violaceous, nontender cutaneous ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Hepatomegaly • Skin ... phenomenon CLL Diagnosis ... Lymphocytosis: Absolute blood ... workup #oncology #hematology
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