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hematology differential causes hemeonc oncology workup agglutinin ascorbicacid chronic classification cll cold common cvid disease extravascular hemolysis hemophagocytic hlh hodgkins
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... microangiopathy: Thrombotic thrombocytopenic ... lymphoproliferative disorders ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder ... #Diagnosis #Algorithm
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
nose, ears, or fingers ... • Symptoms of anemia ... Diagnosis: • hemolytic ... anemia • Cold ... #anemia #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Algorithm Spurious ... • Rheumatic disorders ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #Differential #Diagnosis ... #nonpalpable #dermatology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... acute blood loss, hemolysis ... (BM) ablative disorders ... #Algorithm #Diagnosis ... #Workup #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... 5) Symptoms of anemia ... or thrombocytopenia ... or thrombocytopenia ... #management
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Deficiency) - Diagnosis ... and Management ... contribute to nonimmune hemolysis ... cutaneous vasculitis, thrombocytopenia ... #Management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... specifically immune thrombocytopenia ... and autoimmune hemolytic ... anemia) • Systemic ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... #oncology #management
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