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disease treatment stills adultonset aosd gout activation autoimmune calcium comparison crisis deposition differential hemophagocytic hlh lymphohistiocytosis macrophage mas myopathy myositis
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
culture used to diagnose ... ankles, knees, fingers ... stain and culture- Diagnose ... Gout #Comparison #rheumatology ... #Diagnosis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Differential Diaqnoses ... Stills #Disease #diagnosis ... #management #treatment ... #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... , difficult to diagnose ... malignant) to diagnose ... Disease #AOSD #rheumatology ... #diagnosis #management
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... lasting two weeks or longer ... anti-lL6R, anti-ILI #Adult ... #rheumatology # ... management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... diseases: SLE+++, Adult-onset ... Lymphohistiocytosis #diagnosis ... #management #treatment ... #summary #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
calcium to form CPP ... characterized by sudden onset ... culture used to diagnose ... Deposition #Disease #Rheumatology ... #diagnosis #management
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
and Management ... ankles, knees, fingers ... • Nocturnal onset ... Achilles tendon, fingers ... #rheumatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
injury 2) Abrupt onset ... of arteries Management ... , add other BP meds ... Renal #Crisis #rheumatology ... #management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... cancer-associated adult ... ALS • Very slow onset ... flexors, quadriceps, finger ... Myositis #Myopathy #rheumatology
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