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Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... • Weakness: Starts ... death Miller Fisher ... #management #treatment ... #neurology
NINDS Diagnostic Criteria for Guillain Barre Syndrome 
Features Required for Guillain-Barré Syndrome:
 • Progressive muscle weakness
Criteria for Guillain Barre ... Required for Guillain-Barré ... except in Miller Fisher ... BrighamMedRes #Guillain #Barre ... #criteria #neurology
Guillain-Barre Syndrome
An acute polyneuropathy (disorder Of the peripheral nervous System).
Symptoms are Often symmetrical and progress Over
Guillain-Barre Syndrome ... GuillainBarre #Syndrome ... #Diagnosis #Neurology
Gerstmann Syndrome
1) Finger agnosia - Inability to name their own fingers, affecting both sides
2) Right-left confusion
Gerstmann Syndrome ... 1) Finger agnosia ... name their own fingers ... neudrawlogy #Gerstmann #Syndrome ... #neurology #diagnosis
Characteristic clinical manifestations of Down syndrome 
 
Typical craniofacial appearance 
 • Round face and flat
manifestations of Down syndrome ... • Brushfield spots ... iris (pigmented spots ... incurved fifth finger ... #Downs #Syndrome
Algorithm showing a stepwise approach to the assessment and investigation of a possible neuropathy. CIDP, chronic
GBS, Guillain-Barré ... syndrome; HNPP, ... #Diagnosis #Neurology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Poliomyelitis, Guillain-Barre ... syndrome, Mononeuritis ... Lambert Eaton Syndrome ... differential #diagnosis #neurology
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
CIDP, Guillain-Barre ... Paraprotein-associated (POEMS syndrome ... diagnosis #causes #neurology
Campylobacter
Clinical 
 • Fever 
 • Abdominal pain 
 • Diarrhea (bloody stools) 
 • Vomiting
• Guillain-Barré ... syndrome Management ... Campylobacter #Diagnosis #Management
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... diagnosis #table #neurology