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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Human Immunodeficiency Virus Infected Individuals Induction therapy: • AmBd (0.7–1.0
Recommendations for Cryptococcal ... • AmBd plus fluconazole ... • Fluconazole ... week) >1 year #Cryptococcal ... management #meningitis #cryptococcus
Spectrum of activity for systemic antifungal agents Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
caspofungin; FLU, fluconazole ... Aspergillus fumigatus, Cryptococcus
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Transplant Recipients Induction therapy: • liposomal AmB (3–4 mg/kg per
Recommendations for Cryptococcal ... Consolidation therapy: fluconazole ... Maintenance therapy: fluconazole ... year B-III #Cryptococcal ... management #meningitis #cryptococcus
Antifungal Azoles - Antibiotics Class Overview Mechanism: inhibit ergosterol synthesis (important component of fungal cell membranes)
- Only Fluconazole ... Fluconazole(PO or ... Azoles #Antifungal #Fluconazole
Cryptococcus neoformans Meningoencephalitis- The opening pressure on lumbar puncture was 29 cm of water (reference range,
Cryptococcus neoformans ... The cryptococcal ... CSF culture grew Cryptococcus ... clinical #NEJM #Cryptococcus
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Negative Abscess - Differential ... : Aspergillus, Cryptococcus ... nocardia - Fungal: Cryptococcus ... Coccidiomycosis, Cryptococcus ... Negative #Abscess #Differential
Common Medications Known to Prolong QTc Antiarrhythmics - Amiodarone, sotalol, flecainide, quinidine, dronedarone, dofetilide Vasopressors/inotropes - Epinephrine, norepinephrine,
Antifungals - Fluconazole ... Medications #Causes #differential
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
species including Fluconazole-resistant ... lack activity vs Cryptococcus
Differential diagnosis of Skin + Eye infections • Bacterial: Staph spp, Strep spp, Pseudomonas spp, Bartonella,
Differential diagnosis ... Aspergillus spp, Cryptococcus ... InfectiousDiseases #Infections #Differential
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