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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Human Immunodeficiency Virus Infected Individuals Induction therapy: • AmBd (0.7–1.0
Recommendations for Cryptococcal ... • AmBd plus fluconazole ... • Fluconazole ... week) >1 year #Cryptococcal ... management #meningitis #cryptococcus
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus ... cell walls of Cyptococcus ... fungi #fungus #comparison
Fungal Pneumonias - Diagnosis Comparison Table • Aspergillus • Blastomyces • Candida • Coccidioides • Cryptococcus
Pneumonias - Diagnosis Comparison ... Coccidioides • Cryptococcus ... Pneumonias #Diagnosis #Comparison
Spectrum of activity for systemic antifungal agents Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
caspofungin; FLU, fluconazole ... Aspergillus fumigatus, Cryptococcus
Antifungal Azoles - Antibiotics Class Overview Mechanism: inhibit ergosterol synthesis (important component of fungal cell membranes)
- Only Fluconazole ... Fluconazole(PO or ... Azoles #Antifungal #Fluconazole
Cryptococcus neoformans Meningoencephalitis- The opening pressure on lumbar puncture was 29 cm of water (reference range,
Cryptococcus neoformans ... The cryptococcal ... CSF culture grew Cryptococcus ... clinical #NEJM #Cryptococcus
Cryptococcus neoformans - One Page Diagnosis and Management Summary Dr. Lizzy Hastie @LizzyHastie #Cryptococcus #neoformans #Diagnosis #Management #Treatment
Cryptococcus neoformans ... @LizzyHastie #Cryptococcus
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Transplant Recipients Induction therapy: • liposomal AmB (3–4 mg/kg per
Recommendations for Cryptococcal ... Consolidation therapy: fluconazole ... Maintenance therapy: fluconazole ... year B-III #Cryptococcal ... management #meningitis #cryptococcus
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
species including Fluconazole-resistant ... lack activity vs Cryptococcus
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi •
Paecilomyces, Cryptococcus ... Galactomannan #diagnosis #comparison
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