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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Human Immunodeficiency Virus Infected Individuals
Induction therapy:
 • AmBd (0.7–1.0
Recommendations for Cryptococcal ... • AmBd plus fluconazole ... • Fluconazole ... week) >1 year #Cryptococcal ... management #meningitis #cryptococcus
Important Fungal Stains
Mycology Lab:
 • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus ... cell walls of Cyptococcus
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
caspofungin; FLU, fluconazole ... Aspergillus fumigatus, Cryptococcus
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
- Only Fluconazole ... Fluconazole(PO or ... Azoles #Antifungal #Fluconazole
Cryptococcus neoformans Meningoencephalitis- The opening pressure on lumbar puncture was 29 cm of water (reference range,
Cryptococcus neoformans ... The cryptococcal ... CSF culture grew Cryptococcus ... clinical #NEJM #Cryptococcus
Cryptococcus neoformans - One Page Diagnosis and Management Summary

Dr. Lizzy Hastie @LizzyHastie

#Cryptococcus #neoformans #Diagnosis #Management #Treatment
Cryptococcus neoformans ... @LizzyHastie #Cryptococcus
Causes of Culture Negative Abscess - Differential Diagnosis Framework
Consider prior antibiotics as a cause of a
Negative Abscess - Differential ... : Aspergillus, Cryptococcus ... nocardia - Fungal: Cryptococcus ... Coccidiomycosis, Cryptococcus ... Negative #Abscess #Differential
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Transplant Recipients
Induction therapy:
 • liposomal AmB (3–4 mg/kg per
Recommendations for Cryptococcal ... Consolidation therapy: fluconazole ... Maintenance therapy: fluconazole ... year B-III #Cryptococcal ... management #meningitis #cryptococcus
Causes of CSF Lymphocytic Pleocytosis - Differential Diagnosis
Viral: Arbo, Adeno, Herpes, Entero, HIV
Fungal: Cryptococcus, Cocci, Histo,
Pleocytosis - Differential ... , HIV Fungal: Cryptococcus ... #Pleocytosis #Differential
Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
species including Fluconazole-resistant ... lack activity vs Cryptococcus