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diagnosis oncology hemolytic leukemia management agglutinin algorithm cll common cvid disease extravascular hemeonc immunodeficiency immunology intravascular lymphocytic mds myelodysplasia myelodysplastic
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... inflammatory disorders ... (e.g. autoimmune ... #hematology #secondary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
microangiopathy: Thrombotic thrombocytopenic ... (AIHA)"Cold" (usually ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... • Rheumatic disorders ... effect following treatment ... Iron deficiency anemia ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Secondary Cold ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... leukemia in adults • Disorder ... Infection due to hypogammaglobulinemia ... AIHA, PRCA) • Treatment ... Leukemia #oncology #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... infection risk secondary ... hemolytic anemia ... DDX - Other causes ... #immunology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... , thrombocytopenia ... bone marrow and secondary ... /Cytopenias • AIHA ... #Leukemia #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Causes • Anemia ... Marrow Failure • Chronic ... blood count with differential ... Syndromes #diagnosis #hematology
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