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diagnosis differential hematology algorithm deficiency causes folate folicacid homocysteine mma pancytopenia aafp approach ascorbicacid b12 bariatric bypass comparisontable deficiencies gastric
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
of macrocytic anemia ... elevated, but anemia ... but undiagnosed, folate ... megaloblastic anemia ... #VitaminB12 #Folate
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
Vitamin B12 and/or Folate ... levels of B12 or folate ... Since folate is ... #VitaminB12 #Folate ... Deficiency #Diagnosis #Nutrition
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • B12/folate
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
E - Haemolytic anaemia ... paraesthesiae • Folate ... - Anaemia, neural ... Vitamin B12 - Anaemia ... signs #symptoms #nutrition
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Marrow Failure • Anemia ... Deficiency • Folate ... #MCV #Classification
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
cardiomyopathy) • Folate ... - Macrocytic anemia ... B12 - Macrocytic anemia ... Minerals: • Iron - Anemia ... Bypass #vitamin #nutrition
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate ... have hemolytic anemia ... underlying mild folate ... In addition, folate ... diagnosis #hematology #nutrition
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Deficiency • B12/Folate ... • Anemia of Chronic ... Non-lmmune #Anemia ... #Classification
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... Vitamin B12 • Folate
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
persons with poor nutrition ... breath, wasting, anemia ... Loss of teeth Anemia ... lead to iron and folate ... Pathophysiology #Nutrition
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