29 results
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
. tuberculosis infections ... for 4.6% of new infections ... HIV • Recent infection ... mycobacterial infection ... NTM) • Fungal infection
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
. tuberculosis infections ... for 4.6% of new infections ... HIV • Recent infection ... mycobacterial infection ... NTM) • Fungal infection
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hypogammaglobulinemia -> increased infection ... history of recurrent infections ... disease • Infectious ... community-acquired infections ... Malignancies • Chronic infections
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
Most invasive infections ... HIV/AIDS, CGD) Clinical ... Rhinosinusitis, CNS infection ... , Disseminated infection ... systemic vori Infectious
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... Idiopathic • Infections ... : HCV infection, ... HBV infection, ... HIV infection
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... fraction < 20% Differential ... Diaqnoses: • Infectious ... hepatitis • Pulmonary ... #treatment #rheumatology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Disseminated Infections ... symptoms • Rheumatologic ... infection • Cough ... Fungal #Diagnosis #Management ... #Infections
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... can mimic common infections ... absent NK cell activity ... Treatment: • Infection ... Lymphohistiocytosis #diagnosis #management
Rheumatoid Arthritis Summary
Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders
Signs & Symptoms:
sx improve with activity ... Ultrasound Diagnosis: CLINICAL ... corticosteroid injections ... Arthritis #diagnosis #management ... #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Malignancy • Infections ... thrombophlebitis, pulmonary ... Diagnosis: • + Clinical ... Cryofibrinogenemia DDX ... Cryofibrinogenemia #diagnosis #rheumatology