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diagnosis hepatology differential lfts transaminitis alkaline hepatitis phosphatase biliary chemistry cholangitis cirrhosis comparison disease elevated enzymes gastroenterology hellp hemochromatosis hyophosphatasia
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
ALP - Biliary ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP) ... #FunctionTest #
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... or AST > ALP): ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
phos/ULN ALP) ... specificity to elevated ALP ... GGT/5-NT: ↑ • ALP ... - ALP is from extrahepatic ... normal AST/ALT
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... GGT/5-NT: ↑ - ALP ... , ALP is from extrahepatic ... function may be abnormal
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... ALP: - Enzymes ... - Increased ALP ... Intestine - Other causes ... #Phosphatase #ALP
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... • Pregnancy - AFLP ... disease US — Normal ... #Causes
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... Hepatic imaging: Normal ... to 10-20-fold elevation ... of Pregnancy (AFLP ... diagnosis #icp #HELLP #AFLP
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
in 1923 Low ALP ... synthesized in: liver ... Phosphatase: • Other causes ... • Elevation of ... phosphate &/or • Elevation
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... #Algorithm #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... & AST normal or ... obstruction • ALP ... or higher • Liver
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