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diagnosis hematology acidosis approach causes classification criticalcare dm2 false hba1c hemolytic hgba1c laboratory lactate lactic reduction testing thromboticthrombocytopenicpurpura ttp
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Iron, B-12, or folate ... Reduction == Increase ... HgbA1c #Laboratory #Increase ... #Decrease #Diagnosis ... #DM2 #Differential
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... Deficiency • B12/Folate ... Classification #Approach #Differential ... #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Diagnosis Algorithm ... without platelet decrease ... #workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... result in severe anemia ... Mild-to-moderate elevation ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Lactic Acidosis - Differential ... Shock, Severe Anemia ... Compartment Syndrome • Increased ... Beta-Agonists, ↑ work ... HIV, Malaria, Late
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