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diagnosis causes classification hematology laboratory acidosis approach dehydrogenase dm2 elevated false hba1c hgba1c increase lactic ldh management nephrology reduction rhabdomyolysis
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False Elevation ... Iron, B-12, or folate ... • Hemolytic anemia ... End-stage renal disease ... #DM2 #Differential
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... Deficiency • B12/Folate ... Disease • Marrow ... #Diagnosis #Algorithm
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... result in severe anemia ... Mild-to-moderate elevation ... Serum lactate ... WBC count and differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Pneumocystis pneumonia (late ... Idiosyncratic LDH Elevation ... #LDH #Lactate
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... presentations and disease ... muscle use • Decreased ... 30mmHg) - Severe anemia ... #Differential #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... ULN • AST/ALT Elevation ... vasoconstriction → decreased ... of underlying disease ... Isotonic fluid/Lactated
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